Cellular responses to hypoxia in the pulmonary circulation
نویسندگان
چکیده
منابع مشابه
Cellular responses to hypoxia in the pulmonary circulation.
Hypoxia can be defined as a reduction in available oxygen, whether in a whole organism or in a tissue or cell. It is a real life cause of pulmonary hypertension in humans both in terms of patients with chronic hypoxic lung disease and people living at high altitude. The effect of hypoxia on the pulmonary vasculature can be described in two ways; Hypoxic pulmonary vasoconstriction (HPV) (resulti...
متن کاملHypoxia and the pulmonary circulation.
The first description of the effects of hypoxia on the pulmonary circulation was made by Bradford and Dean in the UK exactly 100 years ago.' However, scientific interest in this field only began with the discovery of hypoxic pulmonary vasoconstriction in the cat by von Euler and Liljestrand2 in 1946, and in man a year later in Andre Coumand's laboratory.3 Despite extensive research in this fiel...
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Hypoxic pulmonary vasoconstriction (HPV) is a beneficial mechanism that diverts blood from hypoxic alveoli to better ventilated areas of the lung, but breathing hypoxic air causes the pulmonary circulation to become hypertensive. Responses to airway hypoxia are associated with depolarization of smooth muscle cells in the pulmonary arteries and reduced activity of K(+) channels. As Kv7 channels ...
متن کاملInvited Review HIGHLIGHTED TOPIC Pulmonary Circulation and Hypoxia Hypoxia, leukocytes, and the pulmonary circulation
Stenmark, Kurt R., Neil J. Davie, John T. Reeves, and Maria G. Frid. Hypoxia, leukocytes, and the pulmonary circulation. J Appl Physiol 98: 715–721, 2005; doi:10.1152/japplphysiol.00840.2004.—Data are rapidly accumulating in support of the idea that circulating monocytes and/or mononuclear fibrocytes are recruited to the pulmonary circulation of chronically hypoxic animals and that these cells ...
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C. M. Littler, C. A. Wehling, M. J. Wick, K. A. Fagan, C. D. Cool, R. O. Messing, and E. C. Dempsey Cardiovascular Pulmonary Research Laboratory and Department of Pathology, University of Colorado Health Sciences Center; and Denver Veterans Administration Medical Center, Denver, Colorado; and Ernest Gallo Clinic and Research Center, Department of Neurology, University of California San Francisc...
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ژورنال
عنوان ژورنال: Thorax
سال: 1998
ISSN: 0040-6376
DOI: 10.1136/thx.53.12.1075